… Hence, MHC I deficiency or CD8 T cell blockade protects … these regulatory CD8 T cells is
lower during MS exacerbations … with irradiated neuroantigen-specific CD4 T cell clones, lyse …

… class I and that neuroantigen-specific CD8 + T cells infiltrate … The concept of anti-neuronal
CD8 + T cell–initiated gray matter … the pathogenic role of neuronal antigen–specific CD8 + T …

… Indeed, adoptive transfer of neuroantigen-specific CD8 + T … of CD8 + Tregs could
restore/improve a deficient immune … factor is critical for regulatory T cell activation and stability. …

… -deficient conditions like multiple sclerosis (MS). Here, we evaluated iTreg formation from
memory versus naïve CD4 + CD25 − T-cell … regulatory T cell homeostasis and function during …

… of activated CD44 high CD25 + regulatory T cell (Treg) populations. IFN-… Multiple sclerosis
(MS) is an inflammatory demyelinating … of disease, together with CD8 + T cells and monocytes/…

… and whether they contribute to the worsening of the condition. It is envisaged that the … immune
adaptive response to optimize regulatory T cell functions [33]. Multiple studies also point to …

… We sought to identify and validate myelin-specific CD8 + T cell epitopes … and functional
reactivity to cognate myelin antigen. Using this approach, we validated 5 myelin CD8 + T cell …

… the regulatory role of CD8 + T cells in MS. Although the impairment of CD8 + T-cell tolerance
is thought to play a crucial role in … Furthermore, PD-1– and PD-L1–deficient mice are more …

… suggests that CD8 T cells may play a significant role in the … T cell found in the CNS in patients
with MS, is the CD8 T cell. As … directly supports a role for T cells in the exacerbation of MS. …

… This argument was based on the realization that 12p40-defective mice did not develop MS
symptoms. … molecules interact to influence T cell function. Effector T cells in multiple sclerosis …